Mikey (Cuba Gooding Junior.) and his stepmother/girlfriend, Rose (Helen Mirren) area unit contract killers. the 2 continue with their line of labor despite the actual fact that Rose is littered with cancer.
Mafia kingpin, Clayton, (Stephen Dorff) suspects that his pregnant better half Vicki (Vanessa Ferlito) might are unfaithful, therefore he hires Mikey and Rose to kill her. Upon coming into Clayton's mansion, Rose heads for Vicki's chamber whereas Vicki is on the phone together with her ally Neisha, (Macy Gray). however as Rose enters Vicki's chamber, Vicki's water breaks and she or he goes into labor. Taking pity on Vicki, Rose uses her previous medical coaching to deliver Vicki's baby, a boy she later names Anthony. Afterward, Mikey and Rose drive Vicki and her child son to a neighborhood court.
At Rose's request, Mikey calls Dr. Don (Joseph Gordon-Levitt), Clayton's personal doctor. Dr. Don arrives along with his drug confirmed nurse/lover, Precious (Mo'Nique). Dr. Don provides medical help to Vicki and her baby before deed. Over Mikey's objections, Rose insists that they take Vicki and her child son to a secure place. The four find yourself in City of Brotherly Love.
Meanwhile, Neisha arrives at Clayton's mansion difficult to grasp wherever Vicki is. Clayton becomes nervous that Neisha is aware of an excessive amount of and pays Mikey to kill her, that he will by poisoning. Mikey and Rose then move Vicki and her son to a house in upstate Pennsylvania. Mikey carries on with the contract killings alone as Rose has become too sick to accompany him.
At the baby's initial celebration, Rose decides she would rather die than suffer from cancer. She and Mikey within the hay make out in the woods, and she or he has Mikey shoot her as she reaches consummation. Before she dies, Rose makes Mikey promise to safeguard Vicki and her baby. Mikey, Vicki, and Anthony live safely for seven years.
Sometime later, Precious discovers Dr. Don activity perversion on a patient. Hurt and betrayed, Precious leaves his workplace whereas threatening to urge her revenge.
Vicki becomes involved regarding Anthony once she sees him looking at Mikey assemble a gun. She later asks Mikey to depart, oral communication that he does not have to be compelled to defend them any longer. Mikey realizes that he has big connected to Anthony and tells Vicki that he needs to remain.
Clayton finds out from Precious that Vicki and Anthony area unit alive. Clayton then kills Precious before of Dr. Don's, then shoots him within the leg. Mikey, deciding that he now not needs to kill, determines that his next contract kill are his final one. once Mikey checks into a building he opens the file on his contract, solely to search out an image of himself and Vicki deed their house. Mikey then calls Vicki. Clayton's bodyguard instead answers the phone, inflicting Mikey to rush home and right into Clayton's lure.
After being captured and tortured, Mikey fights back and defeats Clayton's cohorts. Clayton overpowers Mikey and is near to kill him once he's shot by Anthony. when causation Vicki and Anthony outside, Mikey kills Clayton.Mikey, Vicki, and Anthony escape. Anthony raise Mikey if he's his son, Mikey replies that he's. Mikey conjointly cautions Anthony to look at out for individuals like Clayton and his men; the boy responds, "We'll kill 'em."
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